perscription opioids, like Percocet, Vicodin and Oxycontin. Up to 90% of those
with chronic pain are prescribed an opioid, and up to 25% become addicted. Some people in our bleeding disorder community suffer from chronic pain, especially those with inhibitors and chronic joint damage. I thought it would be good to run this excellent article published in my latest edition of PEN by Paul Clement, our science writer, in our column Inhibitor Insights, sponsored by Novo Nordisk.
stranger to people with hemophilia: joint bleeds are painful, and repeated
bleeds into a joint cause damage to cartilage, resulting in a painful form of
arthritis called hemophilic arthropathy. A trip to your medicine cabinet
usually yields some form of painkiller (analgesic) to get you through the worst
of the pain. But when you have inhibitors, you may need something stronger for prolonged
bleeds or chronic arthropathy.
don’t think twice about taking analgesics. But these meds can potentially kill:
every year, many people overdose accidentally. People with inhibitors frequently
need painkillers and may be at higher risk of serious side effects. When was
the last time you thoroughly read the package insert on your pain med? What do
you need to know to be safe when taking pain meds?
months or longer. Acute pain is considered necessary, even beneficial—alerting
our bodies to danger or injury, and prompting us to protect ourselves or get
treatment. But chronic pain is a disease state in itself, and is often
destructive and debilitating, harming our general well-being.
hemophilia, your acute pain is usually caused by bleeding that leads to
swelling in joints and muscles. Chronic pain, by contrast, is usually caused by
arthritis in joints, a result of repeated bleeds that have damaged the joint’s
cartilage—a common problem for many people with inhibitors. The two types of
pain require different treatment approaches and different pain meds.
of pain depends on the type you have. Pain meds are divided into two broad
groups: opioid and non-opioid.
Mild acute pain—like a headache—is often treated by non-opioid over-the-counter
(OTC) pain meds, available without a doctor’s prescription. There are two basic
types of OTC pain relievers: (1) acetaminophen and (2) a broad class of drugs called
non-steroidal anti-inflammatory drugs (NSAIDs), such as naproxen and ibuprofen.1
such as morphine and oxycodone, are available only with a prescription. These meds
are used to treat moderate-to-severe acute pain and chronic pain.
used as directed, pain meds are usually safe and effective. But when misused,
all pain meds can be dangerous and even deadly. Most drug overdoses are not
intentional, but are caused by ignorance. People don’t read product inserts
carefully, or they combine multiple drugs, not realizing that this could result
in an overdose or make their normally safe medication toxic. Also, many people
believe that because OTC drugs are available without a prescription, they must
be safe and can be taken without harm. Not true! In fact, OTC pain meds are
powerful drugs that can be deadly, and they should be used with caution.
you need to know about pain meds to keep yourself or your child safe? In the
first of this two-part series, we’ll look at the risks of acetaminophen, the
most commonly recommended pain med for people with hemophilia.
hemophilia, acetaminophen (Tylenol®, Excedrin®, Anacin®) is the most often recommended drug for mild to mild–moderate
pain because it’s generally effective, and it doesn’t affect the blood’s
clotting ability, like almost all NSAIDs do. Acetaminophen reduces pain and
fever and won’t cause gastrointestinal bleeding, as NSAIDs can. But
acetaminophen has no anti-inflammatory properties, as NSAIDs do, to help reduce
swelling in joints and muscles.
taken as directed, acetaminophen is generally safe. Over 50 million Americans
use acetaminophen weekly, but it can cause liver damage. Don’t take a higher
dose than is recommended. Don’t take acetaminophen for more than ten days or
while drinking alcohol.
overdose is the leading cause of calls to US poison control centers—more than
100,000 instances annually. Every year, acetaminophen overdose is responsible
for more than 56,000 emergency room visits; 26,000 hospitalizations; and an
estimated 458 deaths due to acute liver failure.2 In fact,
acetaminophen is the number one cause of acute liver failure—placing it above
viral hepatitis as a cause.
half of acetaminophen overdoses are intentional, as in suicide. The other half
are unintentional. Unintentional overdose often occurs because people are
either unaware that acetaminophen can be dangerous, or they mix drugs. Even if
you’re aware of the dangers of acetaminophen, you may not know what’s in the other
drugs you’re taking at the same time. Acetaminophen is found in over 600 drugs,
including many cold medications, and this may not be prominent on the label. Consumers
may also be led astray by a label’s wording: sometimes acetaminophen is
abbreviated “acet” or “acetamin,” or is listed in the ingredients not by its
common name but by the abbreviation of its chemical name: APAP.3 If you’re traveling abroad,
know that in countries outside the US, Canada, and Japan, acetaminophen is called
overdosing on acetaminophen is easy—there isn’t much difference between the
maximum recommended dose and a potentially dangerous dose that is toxic to the
liver. FDA guidelines limit the daily maximum dose of acetaminophen to 4.0
grams (g), or 4,000 milligrams (mg). (1 g equals 1,000 mg.) But for some
people, even taking acetaminophen at below the FDA recommended maximum dose may
be dangerous—a small percentage of people who take acetaminophen can’t
efficiently metabolize (break down) the drug, and they suffer liver damage even
though they are taking less than the recommended maximum daily amount.
McNeil Consumer Healthcare (a Johnson & Johnson company, the manufacturer
of Tylenol and largest seller of acetaminophen) voluntarily lowered its
recommended maximum daily dose from 4.0 g to 3.0 g, that is, from eight
extra-strength (500 mg) tablets to six extra-strength tablets daily.
unintentionally overdose on acetaminophen by taking more than one drug
containing acetaminophen. Suppose you’re taking extra-strength Tylenol (500 mg)
for a joint bleed, and then on top of that, you take NyQuil®
Nighttime Relief (containing 650 mg of acetaminophen) to get some sleep because
you also have a cold. This combination of meds (1,150 mg of acetominophen) may
push you over the 4.0 g daily limit.
also easy to overdose on acetaminophen by taking repeated doses that are only
slightly over the recommended maximum dose. Some people fall into the trap of
thinking that more is better, and knowingly take a little more than the
recommended dose—because it’s “close enough” not to cause problems, right? This
is dangerous thinking! Taking multiple small overdoses, called staggered
overdosing, is often more life-threatening than taking a single, large dose.
Why? It’s harder for physicians to detect staggered overdosing because blood
acetaminophen levels are low (as opposed to a single large dose, which is
easily detected); and often, people often don’t go to a hospital for help until
after the damage is done.
anyone not go to a hospital for acetaminophen overdose? Often, because they
don’t know they have overdosed! An overdose of acetaminophen doesn’t typically
produce immediate symptoms, and when symptoms do appear, they often mimic those
of the flu—often, the reason people are taking acetaminophen in the first place.
of drug-induced liver damage, which may not show for several days or more,
include loss of appetite, nausea, vomiting, fever, and abdominal pain. In more
serious cases, urine may be dark (indicating blood in the urine), and the skin
and eyes may be tinged yellow (called jaundice,
an indication that the liver is not effectively removing the breakdown products
of red blood cells). Usually, if the damage is not severe and caught early, the
liver recovers once the drug is stopped or with medical treatment. But if the
damage is severe, the liver will stop functioning effectively. This is acute
liver failure, and without a transplant, it will cause death. .
acetaminophen, check the package insert for correct dosing.
acetaminophen you need to control your pain.
time that contains acetaminophen!
And never drink alcohol when taking medicines that contain acetaminophen.4
more ways to stay safe:
your daily acetaminophen dose below 3,000 mg (3 g). That’s six extra-strength
500 mg pills, or ten regular-strength 325 mg pills. (This is less than the FDA
not take acetaminophen for more than ten days unless you are under a doctor’s
supervision; this increases your risk of liver damage.
you have viral hepatitis, ask your doctor before using acetaminophen; you may
be at higher risk of drug-induced liver damage due to previous liver damage.
your doctor if you take carbamazepine (anti-seizure medication) before taking
acetaminophen. This drug can put you at higher risk of severe skin reactions to
aware of these rare but serious and potentially fatal skin reactions caused by
acetaminophen: Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis
(TEN), and acute generalized exanthematous pustulosis (AGEP). If you develop a
skin rash or reaction while using acetaminophen, stop taking the drug
and seek medical attention immediately.
you use warfarin (blood thinner, brand name Coumadin®), ask your
doctor before taking acetaminophen, which interacts with warfarin, increasing
child uses acetaminophen:
give your child adult doses.
children based on weight, not age. McNeil Consumer Healthcare recommends
consulting a physician before giving Tylenol to children under age two.
measure liquid acetaminophen for a child, use the measuring device that comes
with the child’s medication. Don’t use household teaspoons, which can vary
widely in size.
all pain medications out of reach of children, and securely replace childproof
of overdose, contact the Poison Control Center: (800) 222-1222
High-dose NSAIDs for moderate acute pain are available by doctor’s prescription.
telephone poll of approximately 1,000 adults conducted by Princeton Survey
Research Associates International, 51% of respondents were unaware of any safety warnings associated with
Tylenol. The poll also found that many Americans also believed it was safe to
take several different meds containing acetaminophen at once. For example, 35%
of respondents said it was safe to combine the maximum recommended dose of extra-strength
Tylenol with NyQuil®, a cold remedy that also contains
acetaminophen. According to the FDA, this is not safe.
greater awareness of the potential of liver damage from acetaminophen, most
drug manufacturers now prominently list acetaminophen in the active ingredients
of the drug facts panel of their products, often in bold type with highlighting
in bright yellow.
More than three alcoholic drinks a day significantly increases your risk of
liver damage by decreasing the ability of your liver to properly metabolize