Richard Atwood

Leeches: A Treatment of Hemophilia


This is an amazing account sent to me by my colleague and the president of Hemophilia of North Carolina, Richard Atwood. Richard is a regular PEN contributor. This article is about…. leeches. Not for the faint of heart.

 

In 1839, Mr. R. Liston at University College Hospital in London, England reported on a case of hereditary hemorrhagic diathesis. His patient, S.P., was a 32-year-old farmer with temperate habits. He was a large man, strong and healthy, with a smooth, fair complexion, dark-grey eyes, dark hair, and sandy whiskers. S.P. reported having lost alarming quantities of blood from extraction of teeth; he was treated with pressure and cautery. At age 19, he had a small wart cut from his hip; he lost so much blood that he fainted and was debilitated for several days. The family history revealed that his maternal grandfather and 6 brothers were also affected with the same peculiarity of constitution.

In February 1839, S.P. fell and hurt his back and loins. Several days later he experienced sudden pain in his left groin, with pain in his left thigh down to his knee. A surgeon examined the subsequent swelling in the groin and ordered leeches. After 2 leeches were applied, the resulting hemorrhage could not be suppressed. The mass in the left groin was about the size of the patient’s fist, similar to a hernia. S.P. was admitted to University College Hospital on March 8, 1839. The abscess was opened with the potassa fusa resulting in slight bleeding. This blood was examined under microscope and found to be deficient of fibrine and in a bad state, containing a proportion of globules characteristic of pus. The patient was discharged… cured.

In 1840, David Burnes MD of Bloomsbury Square, in London, England reported on hemorrhagic diathesis in 3 brothers: 44-year-old William, 30-year-old Charles, and 25-year-old John. In addition, 2 maternal uncles had a tendency to bleed easily, while their mother, 4 sisters, and 3 other brothers, all over 20 years, did not develop this peculiarity.

In July, 1939, William was seized with inflammation of the testis. The usual remedies were ordered including 4 leeches to the scrotum. This treatment removed the disease, but blood continued to ooze from the leech-bites for several days to the point of debilitation. After spontaneous coagulation of the blood over the wounds, William improved much in about 28 days. He then pushed his hand through a pane of glass while opening the window and cut his thumb on the outer side. The free bleeding from the wound was temporarily arrested with adhesive straps until the inflammation of the hand required their removal. The subsequent freely oozing blood continued in spite of the use of styptics, pressure on the radial artery, and ligature. The irritable, greatly debilitated, and almost blanched patient was kept in bed and starved! The treatment of digitalis, ipecacuanha, and nitrate of potash was ordered, along with keeping the wound constantly wet with a lotion of spirit and muriate of ammonia. After a clot formed, the wound healed 24 days from the accident.

Charles, who had a slender frame and great muscular strength, presented in March 1837 for symptoms of enteritis. Charles stated that he and other family members bled easily and declined being bled from the arm. Instead, 6 leeches were applied over the pain on the left side of the umbilicus. This treatment instantly arrested his disease, but blood continued to ooze for 8 days from the leech wounds. After a vexatious confinement to bed caused more by the remedy than the disease, Charles recovered.

While out shooting in October 1827, John fell from his horse and sustained a severe injury to his arm. The day after his biceps were swollen and exceedingly inflamed and his forearm was bruised from elbow to wrist. An order was made for 12 leeches with bleeding encouraged by warm fomentations along with aperients and other medicines. The hemorrhage could not be stopped by pressure, alum, flour, or cobwebs, until nitras argenti was applied. John had constant oozing of blood over several days and subsequently died from loss of blood.

Dr. Burnes noted that hemorrhagic diathesis is hereditary and peculiar to males. He corroborated the opinion that hemorrhagic diathesis arose from a deficiency in the contractile power of the arteries, though he mentioned that the blood seemed less disposed to coagulate and appeared to be mixed with water.

And why leeches? Leeches were used for every kind of ailment during this time in medical history. They certainly didn’t stop bleeding; while attached, leeches secrete hirudin to prevent coagulation of the blood!

References:

Burnes D
1840 Haemorrhagic diathesis Lancet ii:404-406.
Liston R
1839 Haemorrhagic idiosyncrasy. Lancet i:137-8.

Great Book I Just Read
The Johnstown Flood by David McCullough [Kindle edition]

The Johnstown Flood is usually a sidebar and two paragraphs in a high school history book. McCullough, our nation’s master storyteller of American history, makes this a page-turning, electrifying account of the Katrina of the 1880s. You will gasp and may cry while reading this. McCullough at once has given an accurate account, written like a novel, and serves as a memorial. The South Fork Dam served to create an aquatic playground for the super rich of Philadelphia, and despite warnings of the lack of an overflow drain, and various weak spots, nothing was done. Townspeople who lived below the dam often wondered and worried, but no one ever believed anything could possibly go wrong. Then it rained… like the Deluge. And the consequences were as dire. On May 31, 1889, the weakened, earth-made, South Fork Dam burst, and pounded and shredded everything in its path. Trees, dirt, horses, fences, barbed wire gathered like a wall of destruction, hell-bent for Johnstown, its denizens unaware of the horror about to be. Over 2,000 lost their lives in the most horrific ways; entire families of hard working people died. When it was over, grief turned to anger at the rich, at the paparazzi that came to gawk. This is a fascinating story, gut-wrenching and masterfully told. Read it. And take the time to read all the names at the end of those who died. Four stars.

Iraq and Infusions


My friend Richard Atwood keeps finding the most interesting news items in hemophilia. His latest: A British soldier with hemophilia serving in Iraq.

In Bad Days in Basra: My Turbulent Time as Britain’s Man in Southern Iraq, Hilary Synnott, 58, was only weeks away from an early retirement after a career spanning 11 years in the Royal Navy and 30 years in the Diplomatic Service, half of which occurred in developing countries with large Muslim populations.

Then he was asked to be the senior civilian representative in southern Iraq. Synnott agreed to a 6 month tour as head of the Coalition Provisional Authority for the South, based in Basra, in an area holding 4.5 million Iraqis on a quarter of the country’s land mass, and hosting 11,000 British military personnel. The goal of the CPA was to establish a secure, peaceful, and democratic Iraq, but he described the situation as “a bloody mess.”

Funny he should call it that. Synnott underwent a customary medical check which revealed he had mild hemophilia. After another medical check at St. Thomas’s Hospital in London (right next to Big Ben), Synnott commented, “… the doctors provided me with a special medication kit and a supply of needles intended to clot the blood in the event of injury. It was all contained in an insulated plastic bag, to keep the medication cool. I was told to keep the whole lot in a fridge and to learn how to administer the potions myself since the accompanying instructions would be too complicated for non-specialists to follow in a hurry.” Synnott took the factor with him to Basra: “The bag stayed at the bottom of a cupboard, to emerge six months later covered in sand.”

It’s surprising that his hemophilia had not been diagnosed while he served on submarines in the Royal Navy. With regret, Synnott evaluated the civilian contributions as a disappointing failure because it was an impossible situation for a myriad of reasons. The author currently serves as a Senior Fellow at the International Institute for Strategic Studies, and this book sounds like a good read!

Good Book I Just Read
The Red Pony by John Steinbeck
Another good read is this classic. I last read it in high school, and mindful of the high school summer reading list for my daughter, I chose to dust this one off and read it again. I was struck by the very simplistic language, and paucity of creative phrases. Very simple writing, in short sentences, but a poignant story. It’s a marvel how much emotion is betrayed through the simple style. There is also lots of foreshadowing. The story follows Jody, a ten-year-old boy, who receives a red pony as a gift from his emotionally-withdrawn and stern father, and from his warm farm-hand Billy Buck. It’s a sad story, but one you can relate to if you have ever lost a pet. There are also three more short stories about Jody and his family: all portray the simplicity of farm life in dry and hot mid-20th century California, but the complexity in family life, and depths of a child’s mind and heart. Three stars.

North Carolina: A Vital Place in Hemophilia History

I spent the weekend in North Carolina at the state NHF chapter’s annual meeting. Under mild and southern blue skies, we had a good turn out and a jam-packed agenda. Sue Cowell is the excellent executive director of this dynamic chapter, which claims Richard Atwood as its president. It’s interesting that this is one of the few chapters, maybe the only one, where neither the executive director or president have hemophilia or are related to hemophilia. Richard, hobbling about on crutches after breaking his leg recently during a biking fall, joked with the audience that while he doesn’t have hemophilia, “I bleed.”

Laurie Kelley with Sue Cowell

Richard also happens to be a columnist for my newsletter, PEN, and I think knows more about US hemophilia history than anyone, as it’s his passion.

Speakers included:

Ray Stanhope, a long time acquaintance, to represent the NHF and provide an update on activities;

Carl Weixler, past president of Hemophilia Federation of America, to share its programs and activities;

Richard Atwood, who shared the history of hemophilia within North Carolina;

Mike Rosenthal, president of WFH USA, to share programs of the WFH to help those in countries with no access to treatment.

I have to say that Carl is always a delightful speaker and had everyone roaring with laughter when he did an ice breaker: “How to Speak Hillbilly.” Carl is from Kentucky. We were asked to decipher a conversation on the screen, which we couldn’t of course! The conversation ended with: LIB MR DUCKS. Translated: “‘ell, I’ll be! Them are ducks.” So I had to retaliate and quickly fixed my powerpoint to include an icebreaker with Bostonian-speak: “Linder, give the patient a shawt of factah.”

I was fascinated most by Richard’s presentation about North Carolina, especially about a man who bred dogs, and found that they had a mysterious bleeding disorder. After taking them to Chapel Hill to be diagnosed, and learning they had hemophilia, these dogs became the backbone of scientific research into treatment advances for hemophilia, and gene therapy. North Carolina truly has a vital place in hemophilia history. (Photo: with Richard Atwood)

I also spoke at the event, and shared photos and stories of my journeys around the world. We livened things up with a world geography quiz—I even have away money for those with the right answer! The point was to show perspective, which was the theme of the day. Having greater perspective allows greater appreciation. Knowing now the history of North Carolina, you can appreciate its important, and hopefully residents with hemophilia will join the NC chapter’s advocacy efforts at the state house. Greater perspective on how 75% of our community lives worldwide, without treatment, allows greater appreciation of our fortune, even though we may have occasional glitches in treatment. Some of the stories I shared were sad, and the photos heartbreaking. We had a few people cry.

We also had about 5 people approach me to ask to sponsor a child, including the legendary Dr. Harold Roberts, who has also been a keystone in hemophilia treatment innovations. I was very honored just to meet him, let alone accept his kind offer to sponsor a child through my nonprofit Save One Life.

It was a wonderful day to mingle with parents, hear their stories, bump into old friends, like Sam Byers and Larry Cline, both of whom I had met about 13 years ago in the same hotel for a similar event!

After the event, I was able to spend the night with my dear friend and colleague Adriana Henderson, who is renowned for her charitable work with the kids with hemophilia in Romania. She held the first World Hemophilia Day in Romania, and the first camp, Camp Ray of Hope, now in its fourth year. I joke that she does not have a son with hemophilia, but does have about 70 boys with hemophilia. Again, she is not related to hemophilia, and it’s to these people we owe so much.

So, if you are reading this, ask yourself: all these people are so deeply involved in helping others with hemophilia and they are not related. What’s holding you back? There are many who need help, advice, financial aid. Get involved at the local, state, national or international level. Your chapter especially needs you as a voice in the state house. Trust me, you will enjoy it, gain greater perspective on life, and do some good in the world!

PS Our website has had a facelift!!! www.kelleycom.com

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